Pogba is a possible absentee due to fitness concerns after a bout of coronavirus, but this may enable summer signing Van de Beek to make his bow after an unofficial debut against Aston Villa in a friendly at the weekend.
Elsewhere, Greenwood may not start depending on his manager’s feelings following his discipline issues with England.
Martial and Rashford are almost guaranteed starters, while Scott McTominay could get the nod ahead of Nemanja Matic and Fred alongside Van de Beek as the holding central midfielder.
The backline is likely to similar to the one we saw at the end of last season, although Eric Bailly and Victor Lindelof are currently tussling to be Maguire’s partner.
Meanwhile, between the sticks, De Gea may well get the first go, ahead of Henderson, but one slip and he’ll be for the chop.
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